The primary signal is desiredSize on the controller. It can be positive (wants data), zero (at capacity), negative (over capacity), or null (closed). Producers are supposed to check this value and stop enqueueing when it's not positive. But there's nothing enforcing this: controller.enqueue() always succeeds, even when desiredSize is deeply negative.
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Intel's 1986 ICCD paper Performance Optimizations of the 80386 reveals how tightly this was optimized. The entire address translation pipeline -- effective address calculation, segment relocation, and TLB lookup -- completes in 1.5 clock cycles: